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Cost of generic metformin in the United States—the only metformin prescribed in the U.S.—was 2006, as compared with $31.15 in 2000 for a 20 gram metformin pill. However, because cost of metformin itself has remained relatively unchanged, the increase in cost associated with generic substitution is minimal and, in fact, may be positive because generic metformin is in most cases more expensive than original brand-name medication, resulting in a small savings for the insured (see Fig 3 and Table 2). TABLE 2 Cost of generic metformin, 2006 in U.S. Dollars (millions) 2001 2001-04 RANK (THOUSANDS) Dollars ($ millions) 2000 2005 2006 2007 2008 Source: Adapted from IMS Institute for Healthcare Informatics, Cost Estimating Guide for New Generic Drugs, 2010 (September 2010). Although generic metformin increased the overall cost of metformin by eryacne gel buy $2.3 billion over a period of four years, it did so as both a benefit and cost. in that all insurance companies were required to cover the new generic medication, but a cost to the United States of $29.80 per 1000 people in terms of reduced cost and in terms of saved prescription drug usage, due to patients taking less metformin as a result of having generic product available. Additionally, savings from patients being able to access generic brand-name metformin were estimated to be up $4.24 billion, for an overall savings of up to $29.80 per 1000 people. However, the cost drugstore tinted moisturizer canada reduction was not as large for patients with high cardiovascular risk, as the cost savings for this group grew further in the year 2006 relative to 2000—when metformin accounted for on